Targeting
Circulating Breast Tumor Cells to Reduce Metastasis
September 24,
2008 12:30 pm
Radiology Conference
Room N2E14C
Stuart S. Martin, PhD, is an
assistant professor of physiology at the
Dr. Martin
is currently the principal investigator on 4 grants related to breast cancer,
with other major funding pending. His
lab has recently identified 2 novel characteristics of detached breast tumor
cells that provide therapeutic opportunities to destroy circulating tumor
cells, independent of cell division. The lecture today will focus on these
investigations into tubulin microtentacles and the process of apoptotic pathway
imbalance.
Among Dr.
Martin’s publications are:
1. Whipple RA, Balzer EM, Cho EH, Matrone
MA, Yoon JR, Martin, SS. Vimentin
filaments support extension of tubulin-based microtentacles in breast tumor
cells. Cancer Res. 2008;68:5678–5688.
2. Whipple RA, Cheung AM, Martin SS. Detyrosinated microtubule
protrusions in suspended mammary epithelial cells promote reattachment. Exp Cell Res. 2007;313:1326–1336.
3. Zhou F, Leder P, Martin SS. Formin-1 protein associates
with microtubules through a peptide domain encoded by exon-2. Exp Cell Res. 2006;312:1119–1126.
4. Martin SS, Vuori
K. Regulation of Bcl-2 proteins during anoikis and amorphosis. Biochem Biophys Acta. 2004;1692:145–157.
5. Pinkas J, Martin SS, Leder P. Bcl-2-mediated cell survival promotes
metastasis of EpH4 βMEKDD mammary epithelial cells. Mol Cancer Res. 2004;2:551–556.
6. Martin SS,
Ridgeway AG, Pinkas J, et al. A cytoskeleton-based functional genetic screen
identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene. 2004;23:4641–4645.
7. Martin SS,
Leder P. Human mammary epithelial cells undergo apoptosis following actin
depolymerization that is independent of attachment and rescued by Bcl-2. Mol Cell Biol 2001;21: 6529–6536.
8. Nakashima N, Rose DW, Xiao S,
Egawa K, Martin SS, et al. The functional
role of Crk-II in actin cytoskeletal organization and mitogenesis. J Biol Chem. 1999;274:3001–3008.
9. Vollenweider P, Clodi M, Martin SS, Imamura T, Kavanaugh WM,
Olefsky JM. An SH2 domain-containing 5’ inositolphosphatase inhibits
insulin-induced GLUT4 translocation and growth factor-induced actin filament
rearrangement. Mol Cell Biol.
1999;19:1081–1091.
10. Clodi M, Vollenweider P, Klarlund
J, Nakashima N, Martin SS, Czech MP,
Olefsky JM. Effects of general receptor for phosphoinositides-1 on insulin and
insulin-like growth factor I-induced cytoskeletal rearrangement, glucose
transporter-4 translocation, and deoxyribonucleic acid synthesis. Endocrinology. 1998;139:4984–4990.
11. Vollenweider P, Martin SS, Haruta T, et al. The small
guanosine triphosphate-binding protein Rab4 is involved in insulin-induced
GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells. Endocrinology. 1997;138: 4941–4949.
12. Dharmawardhane S, Sanders LC, Martin SS, Daniels RH, Bokoch GM.
Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and
cortical actin structures in stimulated cells. J Cell Biol. 1997;138:1265–1278.
_________________________________________________________
About Diagnostic
Radiology Grand Rounds and CME Credit
Targeted audience: health care providers
Learning objectives: By completing this
educational activity, the participant should gain familiarity with:
(1) The biology of long-term
breast tumor dormancy and metastatic recurrence;
(2) The unique therapeutic
susceptibilities of circulating breast tumor cells; and
(3) The use of confocal microscopy
and whole-animal imaging to track circulating tumor cells.
Sponsored by the
Accreditation & Credit Designation Statements: The University of Maryland School
of Medicine is accredited by the Accreditation Council for Continuing Medical
Education to provide continuing medical education for physicians. The
University of Maryland School of Medicine designates this educational activity
for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only
credit commensurate with the extent of their participation in the activity.